Basic Cyclogest Information

• INN (International Nonproprietary Name): Progesterone.
• Brand Names Available In United Kingdom: Utrogestan.
• ATC Code: G03DA04.
• Forms & Dosages: Soft capsules 100 mg and 200 mg; vaginal capsules/softgels 100 mg and 200 mg.
• Manufacturers In United Kingdom: not specified.
• Registration Status In United Kingdom: Prescription status noted as prescription only (Rx); specific UK marketing authorisation details not specified.
• OTC / Rx Classification: Prescription only (Rx).

Everyday Use — Quick Practical Instructions

Before You Start (UK Warnings)

Are you unsure whether Cyclogest is right for you?

Always treat Cyclogest as a prescribed vaginal progesterone product and discuss it with your GP or fertility clinic before use.

Do not use Cyclogest if you have severe liver disease, known hormone‑dependent cancer, unexplained vaginal bleeding, or a history of thrombosis.

Absolute contraindications include severe hepatic dysfunction, hormone‑dependent malignancies and current or past thromboembolic events.

Check the product leaflet for excipient warnings, such as peanut oil, if you have allergies.

Daily-Life Integration Tips

Worried about leakage or discomfort after insertion?

• Checklist — Before You Use: Confirm prescription with your GP or fertility clinic.
• Check contraindications for liver disease, breast cancer and thrombosis.
• Read the leaflet for excipient/allergy information.
• Confirm storage instructions and expiry date.

Practical daily tips include inserting Cyclogest at night, lying on your back for a few minutes afterwards, and wearing a panty liner to manage discharge.

Avoid intercourse for 1–2 hours if your clinic advises this after insertion.

Keep the pessaries in their original pack and store below 25°C as stated on the leaflet.

Everyday Use & Best Practices

Morning Vs Evening Dosing

Which time of day works best with Cyclogest?

For vaginal Cyclogest, many UK clinics recommend bedtime insertion to reduce leakage and improve comfort.

Bedtime dosing also helps manage any sedative or drowsiness effects that some people notice with progesterone.

For oral micronised progesterone, licensed regimens commonly advise taking the dose at bedtime.

Taking With Or Without Meals (UK Diet Habits)

Will food affect how cyclogest works?

Vaginal Cyclogest is not affected by meals because it delivers progesterone locally.

People who experience nausea with oral micronised progesterone may find taking it with an evening meal reduces gastrointestinal upset.

Avoid heavy late meals and limit alcohol near dosing times because they can increase drowsiness when combined with progesterone.

Daily routine tip: insert Cyclogest after brushing your teeth, before bed, wear a liner and set a phone reminder for consistent dosing.

If you miss a dose, insert as soon as you remember unless the next dose is due, and do not double up.

Safety Priorities

Who Should Avoid It (MHRA Warnings)

Are there clear reasons not to use Cyclogest?

Do not use Cyclogest in severe liver disease, known or suspected breast cancer, other hormone‑dependent tumours, or unexplained vaginal bleeding.

A current or previous history of thrombosis (DVT, PE, stroke, myocardial infarction) is an absolute contraindication.

Check for peanut oil or other allergenic excipients on the packaging, and avoid the product if you have a relevant allergy.

Activities To Limit (Driving, Work Safety)

Could taking Cyclogest affect your ability to drive or work?

Progesterone can cause dizziness, drowsiness or blurred vision in some people.

Avoid driving or operating heavy machinery until you know how the medicine affects you.

If you work in safety‑critical roles, inform occupational health or your clinician and monitor for mood changes.

Do Not Use If…

• you have severe hepatic dysfunction;
• you have hormone‑dependent cancer, including breast cancer;
• you have unexplained vaginal bleeding;
• you have current or past thrombosis;
• you are allergic to an excipient such as peanut oil.

Dosage & Adjustments

General Regimen (NHS Guidance)

How will your clinic tell you to use Cyclogest?

Cyclogest dosing is prescription‑led and depends on the indication, such as luteal support in fertility treatment or endometrial protection with HRT.

Progesterone is available in multiple forms and strengths; vaginal forms are commonly used in fertility and some HRT regimens.

Typical labelled oral regimens include examples such as 200 mg once daily at bedtime for endometrial protection, or 400 mg at bedtime for secondary amenorrhoea as per product literature, but follow your prescriber’s directions.

Special Cases (Elderly, Comorbidities)

Do older people need a lower dose?

No routine dose reduction is mandated for elderly people, but increased sensitivity should be monitored and side effects checked regularly.

Avoid use in severe hepatic impairment and use caution with renal impairment.

If you miss a dose, insert or take it as soon as remembered unless it is almost time for the next dose, and never double the dose.

Overdose can cause nausea, vomiting, withdrawal bleeding or sedation; seek medical advice if this occurs.

User Testimonials

Positive Reports From UK Patients

Will Cyclogest help with fertility side‑effects while keeping nausea at bay?

Many UK patients report Cyclogest gives targeted support for implantation and early fertility treatment with fewer systemic side effects than oral progesterone.

Users often praise reduced nausea compared with oral micronised progesterone and find bedtime vaginal dosing convenient.

Common Challenges (Patient.info, NHS Forums)

What problems do people commonly report?

On NHS forums and Patient.info, common issues include local irritation, increased discharge, leakage and occasional cramping.

Some people find insertion awkward or experience discomfort during intercourse.

Systemic effects such as drowsiness and mood changes are more frequently reported with oral progesterone than with vaginal pessaries.

Pros

• Localised action with often fewer systemic side effects.
• Helpful for luteal support in fertility treatment.
• Convenient for those who struggle with oral tablets.

Cons

• Local discharge and leakage.
• Potential insertion difficulty for some people.
• Local irritation or cramping in some users.

Keep a record of side effects and report them to your GP, fertility clinic or pharmacist for practical solutions.

Buying Guide

Pharmacy Sources (Boots, LloydsPharmacy, Superdrug)

How do you get Cyclogest in the UK?

Cyclogest is prescription‑only and should be requested via an NHS prescription from your GP or supplied via a private fertility clinic.

Private prescriptions can be dispensed at major UK chains and independent pharmacies, and MHRA‑registered online pharmacies will supply on receipt of a valid prescription.

Pharmacies can advise on insertion technique and managing local irritation when you collect the medicine.

Price Comparison (NHS Prescription Charge Vs Private)

How much will it cost?

In England a prescription charge usually applies unless you are exempt, while Scotland, Wales and Northern Ireland generally offer free prescriptions.

Private clinic prescriptions will often incur a charge and private prices vary between pharmacies.

Compare local stock and private prices if paying privately, and ask the pharmacist for written instructions if you need them.

In our online pharmacy, Cyclogest can be dispensed on a valid prescription, with discreet delivery to United Kingdom in 5-14 days.

What’s Inside & How It Works

Ingredients Overview

What exactly is in Cyclogest?

The active ingredient is progesterone (INN: progesterone), typically delivered as micronised progesterone in softgel or pessary form.

Excipients vary by product; check the leaflet for allergens such as peanut oil.

Mechanism Basics Explained Simply

How does progesterone support fertility or HRT?

Progesterone prepares and supports the lining of the womb (the endometrium) to make it receptive for implantation and to support early pregnancy.

In HRT it provides endometrial protection when given with oestrogen.

Vaginal delivery concentrates progesterone at the endometrium and often reduces systemic side effects seen with oral routes.

Vaginal Cyclogest is a pessary delivering micronised progesterone locally to mimic the natural luteal‑phase environment.

Main Indications

Approved Uses (MHRA Listing)

Why might your clinician prescribe Cyclogest?

Cyclogest and other vaginal progesterone preparations are widely used for luteal support in assisted reproduction and as endometrial protection with oestrogen in HRT.

Progesterone is also licensed for secondary amenorrhoea in some product literature.

Off-Label Uses In UK Clinics

Do clinics sometimes use it differently?

UK fertility clinics may adopt vaginal progesterone regimens that vary from oral labels, following clinical practice guidelines across Europe.

Follow your clinic’s specific schedule for start/stop timing relative to ovulation or embryo transfer.

Do not self‑prescribe or change your regimen based on internet sources without clinician approval.

Interaction Warnings

Food Interactions (Alcohol, Tea/Coffee)

Will food or drink affect Cyclogest?

Vaginal Cyclogest has minimal direct food interactions, because it acts locally.

Alcohol and high caffeine intake can exacerbate drowsiness or headaches associated with progesterone; avoid heavy alcohol near dosing times.

Drug Conflicts (MHRA Yellow Card Reports)

Could other medicines change how well it works?

Systemic progesterone may interact with enzyme inducers, such as some antiepileptic medicines and rifampicin, which can reduce progesterone levels.

Provide your full medication list, including over‑the‑counter products and herbal supplements, to your prescriber and pharmacist.

Report suspected adverse reactions via the MHRA Yellow Card scheme and tell your prescriber about severe or unexpected effects.

Latest Evidence & Insights

Key UK & EU Studies 2022–2025

What does the recent research say about vaginal progesterone?

Recent UK and EU literature from 2022–2025 supports vaginal progesterone for luteal support in assisted reproduction, showing comparable pregnancy outcomes and often fewer systemic side effects than oral synthetic progestins.

Micronised progesterone formulations, both oral and vaginal, continue to be studied and used in clinical practice.

Practical Takeaways For Patients

What should patients take away from the evidence?

Vaginal delivery concentrates progesterone at the womb lining, reducing some systemic adverse effects and making vaginal pessaries such as Cyclogest a common choice in fertility settings.

Discuss formulation choice with your clinician if you have a history of mood change, migraines or clotting disorders.

For further reading, consult NHS fertility information and systematic reviews summarising vaginal versus oral progesterone strategies.

Alternative Choices

NHS Prescribing Alternatives With Pros/Cons Checklist

What other medicines might be considered instead of Cyclogest?

Alternatives include oral micronised progesterone preparations such as Utrogestan or Prometrium, synthetic progestins like medroxyprogesterone (Provera) and dydrogesterone (Duphaston), and other vaginal formulations such as gels or pessaries (for example Crinone or Endometrin in some markets).

Pros/Cons Checklist

• Vaginal Cyclogest: Pros — local action, fewer systemic effects; Cons — local discharge and insertion issues.
• Oral Micronised Progesterone (Utrogestan/Prometrium): Pros — familiar oral dosing; Cons — may cause more drowsiness or gastrointestinal side effects.
• Synthetic Progestins (Duphaston/Provera): Pros — oral tablets with different side‑effect profile; Cons — not bioidentical progesterone and may have different risks.

Discuss options with your GP or fertility clinic to match efficacy, side‑effect profile and personal preference.

Regulation Snapshot

MHRA Approval & Safety Monitoring

How is Cyclogest monitored in the UK?

Progesterone products are prescription only and safety is monitored through the MHRA Yellow Card system, which accepts reports of suspected adverse reactions.

UK prescribers follow MHRA advice on contraindications such as severe hepatic disease, hormone‑dependent tumours and thromboembolic events.

NHS Prescribing Framework

How will the NHS handle prescriptions?

Prescriptions are issued by GPs, hospital specialists or private clinics and dispensed at NHS or private pharmacies.

Prescription charging differs across the UK: England usually charges unless exempt, while Scotland, Wales and Northern Ireland generally provide free prescriptions.

Ask your pharmacist for the patient information leaflet and keep batch numbers if you need to report adverse events.

FAQ — Common UK Patient Questions

How Will Cyclogest Affect My Day-To-Day Life?

Will it make me sleepy?

Vaginal use usually has less systemic impact than oral progesterone, but some people may still feel drowsy so bedtime dosing is commonly advised as a precaution.

What If I Miss A Dose Or Have Side Effects?

Can I double up if I forget?

Insert a missed dose as soon as you remember unless it is very close to the next dose; do not double up.

Report serious or unexpected side effects to your prescriber and via the MHRA Yellow Card scheme.

Contact your fertility clinic for timing‑sensitive missed doses related to embryo transfer or ovulation.

Guidelines For Proper Use

UK Pharmacist Counselling Style

What will the pharmacist tell you when you collect Cyclogest?

A pharmacist should confirm your indication and dosing schedule, demonstrate or explain insertion technique if needed, and warn about contraindications such as liver disease and thromboembolism.

They should check for excipient allergies and advise on side‑effect monitoring and follow‑up arrangements.

NHS Patient Support Advice

Who should you contact with questions?

Use your GP, fertility clinic nurse or community pharmacist for questions about Cyclogest.

Report adverse events to the MHRA Yellow Card scheme and inform your prescriber of any problems.

Expect periodic reviews if you are on repeated cycles or HRT to reassess risks such as clotting or mood changes and consider switching formulations if problems persist.

Delivery Across United Kingdom